1. M. Hollerhage, A. Matusch, P. Champy, A. Lombes, M. Ruberg, W. H. Oertel, and G. U. Hoglinger. Natural lipophilic inhibitors of mitochondrial complex I are candidate toxins for sporadic neurodegenerative tau pathologies. Exp Neurol, 2009. Note: Journal article. [WWW]



2. F. Schmidt, P. Champy, B. Seon-Meniel, X. Franck, R. Raisman-Vozari, and B. Figadere. Chemicals possessing a neurotrophin-like activity on dopaminergic neurons in primary culture. PLoS One, 4(7):e6215, 2009. Note: Journal ArticleResearch Support, Non-U.S. Gov'tUnited States. [WWW]



3. M. Escobar-Khondiker, M. Hollerhage, M. P. Muriel, P. Champy, A. Bach, C. Depienne, G. Respondek, E. S. Yamada, A. Lannuzel, T. Yagi, E. C. Hirsch, W. H. Oertel, R. Jacob, P. P. Michel, M. Ruberg, and G. U. Hoglinger. Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons. J Neurosci, 27(29):7827-37, 2007. Note: Dk053244/dk/niddkNs048441/ns/nindsJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tUnited Statesthe official journal of the Society for Neuroscience. [WWW] Keyword(s): Adenosine Triphosphate/metabolism, Animals, Brain/cytology, Cell Death/drug effects, Cell Survival/drug effects, Cells, Cultured, Dose-Response Relationship, Drug, Embryo, Enzyme Inhibitors/*pharmacology, Female, Furans/*pharmacology, Lactones/*pharmacology, Microscopy, Immunoelectron/methods, Microtubule-Associated Proteins/metabolism, Neurons/*drug effects/metabolism/ultrastructure, Paclitaxel/pharmacology, Pregnancy, Rats, Rats, Wistar, Reactive Oxygen Species/metabolism, Tubulin Modulators/pharmacology, tau Proteins/*metabolism.



4. A. Lannuzel, G. U. Hoglinger, P. Champy, P. P. Michel, E. C. Hirsch, and M. Ruberg. Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae?. J Neural Transm Suppl, (70):153-7, 2006. Note: Journal ArticleAustria. [WWW] Keyword(s): Adenosine Triphosphate/metabolism, Alkaloids/isolation & purification/toxicity, Animals, Annonaceae/*adverse effects, Cells, Cultured, Fruit, Furans/isolation & purification/toxicity, Lactones/isolation & purification/toxicity, Male, Medicine, Herbal, Mesencephalon/cytology, Neostriatum/pathology, Nerve Degeneration/chemically induced/pathology, Parkinson Disease, Secondary/*chemically induced/epidemiology, Plant Extracts/adverse effects, Plant Leaves/chemistry, Rats, Rats, Inbred Lew, Substantia Nigra/pathology, West Indies/epidemiology.



5. P. Champy, A. Melot, V. Guerineau Eng, C. Gleye, D. Fall, G. U. Hoglinger, M. Ruberg, A. Lannuzel, O. Laprevote, A. Laurens, and R. Hocquemiller. Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe. Mov Disord, 20(12):1629-33, 2005. Note: Comparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tUnited Statesofficial journal of the Movement Disorder Society. [WWW] Keyword(s): Annona/*chemistry/toxicity, Chromatography, High Pressure Liquid/methods, Fatty Alcohols/*adverse effects/*analysis/chemistry, Guadeloupe/epidemiology, Humans, Lactones/*adverse effects/*analysis/chemistry, Molecular Weight, Parkinsonian Disorders/*etiology, Plant Extracts/adverse effects/analysis/chemistry, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods.



6. G. U. Hoglinger, A. Lannuzel, M. E. Khondiker, P. P. Michel, C. Duyckaerts, J. Feger, P. Champy, A. Prigent, F. Medja, A. Lombes, W. H. Oertel, M. Ruberg, and E. C. Hirsch. The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy. J Neurochem, 95(4):930-9, 2005. Note: Comparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tEngland. [WWW] Keyword(s): Amyloid beta-Protein/metabolism, Analysis of Variance, Animals, Antineoplastic Combined Chemotherapy Protocols/metabolism, Behavior, Animal, Body Weight/drug effects, Caspase 3, Caspases/metabolism, Cell Death/drug effects, Cerebral Cortex/*drug effects/pathology/physiopathology, Cytarabine/metabolism, Diagnostic Imaging/methods, Dopamine and cAMP-Regulated Phosphoprotein 32/metabolism, Doxorubicin/metabolism, Dystonia/etiology/physiopathology, Electron Transport Complex III/metabolism, Enzyme Activation/drug effects, Glial Fibrillary Acidic Protein/metabolism, Immunohistochemistry/methods, Locomotion/drug effects, Male, Microscopy, Electron, Transmission/methods, Mitochondria/drug effects/ultrastructure, Neurons/drug effects/physiology, Phosphopyruvate Hydratase/metabolism, Phosphorylation, Posture, Psychomotor Performance/drug effects, Rats, Rats, Inbred Lew, Rotenone/*adverse effects, Tauopathies/*chemically induced/pathology/physiopathology, Thiazoles/diagnostic use, Time Factors, Tyrosine/analogs & derivatives/metabolism, Tyrosine 3-Monooxygenase/metabolism, Ubiquitin/metabolism, Uncoupling Agents/*adverse effects, alpha-Synuclein/metabolism, tau Proteins/metabolism.



7. G. U. Hoglinger, P. P. Michel, P. Champy, J. Feger, E. C. Hirsch, M. Ruberg, and A. Lannuzel. Experimental evidence for a toxic etiology of tropical parkinsonism. Mov Disord, 20(1):118-9, 2005. Note: CommentComparative StudyLetterUnited Statesofficial journal of the Movement Disorder Society. [WWW] Keyword(s): Adenosine Triphosphate/metabolism, Alkaloids/toxicity, Animals, Annonaceae/chemistry/*toxicity, Brain/cytology/drug effects, Cells, Cultured, Fatty Alcohols/toxicity, Humans, Lactones/toxicity, Mitochondrial Diseases/complications/etiology, Neurons/drug effects, Pacific Islands, Parkinsonian Disorders/*etiology, Rats.



8. P. Champy, G. U. Hoglinger, J. Feger, C. Gleye, R. Hocquemiller, A. Laurens, V. Guerineau, O. Laprevote, F. Medja, A. Lombes, P. P. Michel, A. Lannuzel, E. C. Hirsch, and M. Ruberg. Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe. J Neurochem, 88(1):63-9, 2004. Note: Journal ArticleResearch Support, Non-U.S. Gov'tEngland. [WWW] Keyword(s): Adenosine Triphosphate/metabolism, Animals, Behavior, Animal/drug effects, Cell Count, Corpus Striatum/*drug effects/metabolism/pathology, Electron Transport Complex I/*antagonists & inhibitors, Furans/administration & dosage/*toxicity, Gliosis/chemically induced/pathology, Guadeloupe, Infusions, Intravenous, Lactones/administration & dosage/*toxicity, Male, Mitochondria/enzymology, Neurodegenerative Diseases/*chemically induced/enzymology/pathology, Neurons/drug effects/pathology, Parkinsonian Disorders/etiology, Plant Extracts/administration & dosage/*toxicity, Rats, Rats, Inbred Lew, Substantia Nigra/*drug effects/metabolism/pathology.



9. G. U. Hoglinger, J. Feger, A. Prigent, P. P. Michel, K. Parain, P. Champy, M. Ruberg, W. H. Oertel, and E. C. Hirsch. Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats. J Neurochem, 84(3):491-502, 2003. Note: Journal ArticleResearch Support, Non-U.S. Gov'tEngland. [WWW] Keyword(s): Animals, Behavior, Animal/drug effects, Cell Count, Choline O-Acetyltransferase/biosynthesis, Chronic Disease, Corpus Striatum/drug effects/pathology, Disease Models, Animal, Dopamine and cAMP-Regulated Phosphoprotein 32, Drug Administration Schedule, Electron Transport Complex I, Enzyme Inhibitors/administration & dosage/*toxicity, Inclusion Bodies/pathology, Infusions, Intravenous, Locus Coeruleus/drug effects/pathology, Male, Mesencephalon/drug effects/pathology, Motor Activity/drug effects, Movement Disorders/complications/etiology/*pathology, NADH, NADPH Oxidoreductases/*antagonists & inhibitors, *Nerve Tissue Proteins, Neurodegenerative Diseases/chemically induced/complications/*pathology, Neuroglia/pathology, Neurons/drug effects/metabolism/pathology, Pesticides/toxicity, Phosphoproteins/biosynthesis, Rats, Rats, Inbred Lew, Rotenone/administration & dosage/*toxicity, Serotonin/biosynthesis, Substantia Nigra/drug effects/pathology, Time, Tyrosine 3-Monooxygenase/biosynthesis.



10. A. Lannuzel, P. P. Michel, G. U. Hoglinger, P. Champy, A. Jousset, F. Medja, A. Lombes, F. Darios, C. Gleye, A. Laurens, R. Hocquemiller, E. C. Hirsch, and M. Ruberg. The mitochondrial complex I inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism. Neuroscience, 121(2):287-96, 2003. Note: Comparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tUnited States. [WWW] Keyword(s): 1-Methyl-4-phenylpyridinium/toxicity, Acetylcysteine/pharmacology, Adenosine Triphosphate/analysis, Animals, Antioxidants/pharmacology, Benzodiazepines/pharmacology, Cell Survival, Cells, Cultured, Chromans/pharmacology, Deoxyglucose/metabolism, Dizocilpine Maleate/pharmacology, Dopamine/*metabolism, Dose-Response Relationship, Drug, Drug Interactions, Embryo, Energy Metabolism/*drug effects/physiology, Excitatory Amino Acid Antagonists, Female, Furans/chemistry/*toxicity, Glucose/pharmacology, Herbicides/toxicity, Hexoses/pharmacology, Insecticides/toxicity, Intracellular Space/metabolism, Lactones/chemistry/*toxicity, Male, Mannose/pharmacology, Mesencephalon/cytology/*drug effects/physiology, Microtubule-Associated Proteins/metabolism, Mitochondria/*drug effects, Neurons/*drug effects/physiology, Neurotoxins/chemistry/*toxicity, Plant Extracts/chemistry/toxicity, Pregnancy, Rats, Rats, Wistar, Reactive Oxygen Species, Rotenone/toxicity, Tritium/metabolism, Tyrosine 3-Monooxygenase/metabolism.

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