1. M. Domercq, M. V. Sanchez-Gomez, C. Sherwin, E. Etxebarria, R. Fern, and C. Matute. System xc- and glutamate transporter inhibition mediates microglial toxicity to oligodendrocytes. J Immunol, 178(10):6549-56, 2007. Note: Ns44875/ns/nindsJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tUnited States1950). [WWW] Keyword(s): Amino Acid Transport System X-AG/*antagonists & inhibitors/toxicity, Animals, Cell Death/physiology, Cells, Cultured, Coculture Techniques, Cystine/metabolism, Excitatory Postsynaptic Potentials/*physiology, Glutamic Acid/metabolism/toxicity, Homeostasis/physiology, Inflammation Mediators/*antagonists & inhibitors/toxicity, Lipopolysaccharides/toxicity, Microglia/*metabolism/physiology, Oligodendroglia/*metabolism/*pathology/physiology, Optic Nerve/metabolism/pathology/physiology, Rats, Rats, Sprague-Dawley, Reactive Oxygen Species/toxicity.



2. C. Matute, I. Torre, F. Perez-Cerda, A. Perez-Samartin, E. Alberdi, E. Etxebarria, A. M. Arranz, R. Ravid, A. Rodriguez-Antiguedad, M. Sanchez-Gomez, and M. Domercq. P2X(7) receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitis. J Neurosci, 27(35):9525-33, 2007. Note: Journal ArticleResearch Support, Non-U.S. Gov'tUnited Statesthe official journal of the Society for Neuroscience. [WWW] Keyword(s): Adenosine Triphosphate/*toxicity, Animals, Animals, Newborn, Calcium/metabolism, Cell Survival/drug effects/physiology, Cells, Cultured, Encephalomyelitis, Autoimmune, Experimental/chemically induced/*therapy, Glial Fibrillary Acidic Protein/metabolism, Glycoproteins, Humans, Membrane Potentials/drug effects/physiology/radiation effects, Mice, Microscopy, Immunoelectron/methods, Myelin Basic Proteins/metabolism, Oligodendroglia/*drug effects/metabolism/ultrastructure, Optic Nerve/cytology/pathology/ultrastructure, Patch-Clamp Techniques/methods, Peptide Fragments, Platelet Aggregation Inhibitors, Rats, Rats, Sprague-Dawley, Receptors, Purinergic P2/*antagonists & inhibitors/*physiology.



3. M. Domercq, E. Etxebarria, A. Perez-Samartin, and C. Matute. Excitotoxic oligodendrocyte death and axonal damage induced by glutamate transporter inhibition. Glia, 52(1):36-46, 2005. Note: Journal ArticleResearch Support, Non-U.S. Gov'tUnited States. [WWW] Keyword(s): Amino Acid Transport System X-AG/antagonists & inhibitors/*metabolism, Animals, Animals, Newborn, Brain/*metabolism/physiopathology, Brain Damage, Chronic/etiology/*metabolism/physiopathology, Cell Death/physiology, Cells, Cultured, Demyelinating Diseases/chemically induced/metabolism/physiopathology, Enzyme Inhibitors/pharmacology, Excitatory Amino Acid Antagonists/pharmacology, Excitatory Amino Acid Transporter 1/antagonists & inhibitors/metabolism, Excitatory Amino Acid Transporter 2/antagonists & inhibitors/metabolism, Glutamic Acid/*metabolism/pharmacology, Neurotoxins/metabolism/pharmacology, Oligodendroglia/drug effects/*metabolism, Oligodeoxyribonucleotides, Antisense/pharmacology, Optic Nerve Diseases/chemically induced/metabolism/physiopathology, Patch-Clamp Techniques, Rats, Rats, Sprague-Dawley, Receptors, AMPA/antagonists & inhibitors/metabolism, Receptors, Kainic Acid/antagonists & inhibitors/metabolism, Wallerian Degeneration/etiology/*metabolism/physiopathology.

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