1. M. Hollerhage, A. Matusch, P. Champy, A. Lombes, M. Ruberg, W. H. Oertel, and G. U. Hoglinger. Natural lipophilic inhibitors of mitochondrial complex I are candidate toxins for sporadic neurodegenerative tau pathologies. Exp Neurol, 2009. Note: Journal article. [WWW]



2. D. Alvarez-Fischer, C. Henze, C. Strenzke, J. Westrich, B. Ferger, G. U. Hoglinger, W. H. Oertel, and A. Hartmann. Characterization of the striatal 6-OHDA model of Parkinson's disease in wild type and alpha-synuclein-deleted mice. Exp Neurol, 210(1):182-93, 2008. Note: Journal ArticleResearch Support, Non-U.S. Gov'tUnited States. [WWW] Keyword(s): Adrenergic Agents/*toxicity, Animals, Behavior, Animal/drug effects, Brain Chemistry/drug effects, Corpus Striatum/*drug effects, Disease Models, Animal, Dose-Response Relationship, Drug, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Motor Activity/drug effects, Oxidopamine/*toxicity, *Parkinson Disease/etiology/genetics/physiopathology, Rotarod Performance Test/methods, Substantia Nigra/metabolism, Time Factors, Tyrosine 3-Monooxygenase/metabolism, alpha-Synuclein/*deficiency.



3. D. Alvarez-Fischer, G. Blessmann, C. Trosowski, M. Behe, T. Schurrat, A. Hartmann, T. M. Behr, W. H. Oertel, G. U. Hoglinger, and H. Hoffken. Quantitative [(123)I]FP-CIT pinhole SPECT imaging predicts striatal dopamine levels, but not number of nigral neurons in different mouse models of Parkinson's disease. Neuroimage, 38(1):5-12, 2007. Note: Journal ArticleUnited States. [WWW]



4. C. Depboylu, A. Matusch, F. Tribl, M. Zoriy, P. P. Michel, P. Riederer, M. Gerlach, S. Becker, W. H. Oertel, and G. U. Hoglinger. Glia protects neurons against extracellular human neuromelanin. Neurodegener Dis, 4(2-3):218-26, 2007. Note: Journal ArticleResearch Support, Non-U.S. Gov'tSwitzerland. [WWW]



5. M. Escobar-Khondiker, M. Hollerhage, M. P. Muriel, P. Champy, A. Bach, C. Depienne, G. Respondek, E. S. Yamada, A. Lannuzel, T. Yagi, E. C. Hirsch, W. H. Oertel, R. Jacob, P. P. Michel, M. Ruberg, and G. U. Hoglinger. Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons. J Neurosci, 27(29):7827-37, 2007. Note: Dk053244/dk/niddkNs048441/ns/nindsJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tUnited Statesthe official journal of the Society for Neuroscience. [WWW] Keyword(s): Adenosine Triphosphate/metabolism, Animals, Brain/cytology, Cell Death/drug effects, Cell Survival/drug effects, Cells, Cultured, Dose-Response Relationship, Drug, Embryo, Enzyme Inhibitors/*pharmacology, Female, Furans/*pharmacology, Lactones/*pharmacology, Microscopy, Immunoelectron/methods, Microtubule-Associated Proteins/metabolism, Neurons/*drug effects/metabolism/ultrastructure, Paclitaxel/pharmacology, Pregnancy, Rats, Rats, Wistar, Reactive Oxygen Species/metabolism, Tubulin Modulators/pharmacology, tau Proteins/*metabolism.



6. G. U. Hoglinger, J. J. Breunig, C. Depboylu, C. Rouaux, P. P. Michel, D. Alvarez-Fischer, A. L. Boutillier, J. Degregori, W. H. Oertel, P. Rakic, E. C. Hirsch, and S. Hunot. The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease. Proc Natl Acad Sci U S A, 104(9):3585-90, 2007. Note: R24 mh 68855/mh/nimhComparative StudyJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tUnited States. [WWW] Keyword(s): 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine/pharmacology, 1-Methyl-4-phenylpyridinium/pharmacology, Analysis of Variance, Animals, Apoptosis/*physiology, Chromatography, High Pressure Liquid, E2F1 Transcription Factor/genetics/*metabolism, Gene Expression Regulation/drug effects, Humans, Immunohistochemistry, In Situ Hybridization, Interneurons/drug effects/*metabolism, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Oligonucleotides, Antisense/genetics, Parkinson Disease/*physiopathology, Signal Transduction/drug effects, Substantia Nigra/*metabolism.



7. A. Lannuzel, G. U. Hoglinger, S. Verhaeghe, L. Gire, S. Belson, M. Escobar-Khondiker, P. Poullain, W. H. Oertel, E. C. Hirsch, B. Dubois, and M. Ruberg. Atypical parkinsonism in Guadeloupe: a common risk factor for two closely related phenotypes?. Brain, 130:816-827, 2007. Note: Part 3. [WWW]



8. B. Nait-Oumesmar, N. Picard-Riera, C. Kerninon, L. Decker, D. Seilhean, G. U. Hoglinger, E. C. Hirsch, R. Reynolds, and A. Baron-Van Evercooren. Activation of the subventricular zone in multiple sclerosis: Evidence for early glial progenitors. Proc Natl Acad Sci U S A, 104(11):4694-9, 2007. Note: Journal ArticleUnited States. [WWW]



9. N. Freundlieb, C. Francois, D. Tande, W. H. Oertel, E. C. Hirsch, and G. U. Hoglinger. Dopaminergic substantia nigra neurons project topographically organized to the subventricular zone and stimulate precursor cell proliferation in aged primates. J Neurosci, 26(8):2321-5, 2006. Note: Journal ArticleResearch Support, Non-U.S. Gov'tUnited Statesthe official journal of the Society for Neuroscience. [WWW] Keyword(s): Aging/*metabolism/pathology, Animals, Cell Differentiation/physiology, Cell Proliferation, Cells, Cultured, Cercopithecus aethiops, Cerebral Ventricles/*cytology/metabolism, Dopamine/*metabolism, Macaca mulatta, Neural Pathways/cytology/metabolism, Neurons/*cytology/*metabolism, Stem Cells/*cytology/metabolism, Substantia Nigra/*cytology/metabolism, Tissue Distribution.



10. G. U. Hoglinger, W. H. Oertel, and E. C. Hirsch. The rotenone model of parkinsonism--the five years inspection. J Neural Transm Suppl, (70):269-72, 2006. Note: Journal ArticleReviewAustria. [WWW] Keyword(s): Animals, Disease Models, Animal, Dopamine/physiology, Humans, Movement/drug effects/physiology, Neurodegenerative Diseases/chemically induced/pathology, Neurons/pathology, Parkinson Disease, Secondary/*chemically induced/pathology/physiopathology, *Rotenone, Substantia Nigra/pathology, *Uncoupling Agents, tau Proteins/metabolism.



11. A. Lannuzel, G. U. Hoglinger, P. Champy, P. P. Michel, E. C. Hirsch, and M. Ruberg. Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae?. J Neural Transm Suppl, (70):153-7, 2006. Note: Journal ArticleAustria. [WWW] Keyword(s): Adenosine Triphosphate/metabolism, Alkaloids/isolation & purification/toxicity, Animals, Annonaceae/*adverse effects, Cells, Cultured, Fruit, Furans/isolation & purification/toxicity, Lactones/isolation & purification/toxicity, Male, Medicine, Herbal, Mesencephalon/cytology, Neostriatum/pathology, Nerve Degeneration/chemically induced/pathology, Parkinson Disease, Secondary/*chemically induced/epidemiology, Plant Extracts/adverse effects, Plant Leaves/chemistry, Rats, Rats, Inbred Lew, Substantia Nigra/pathology, West Indies/epidemiology.



12. P. Champy, A. Melot, V. Guerineau Eng, C. Gleye, D. Fall, G. U. Hoglinger, M. Ruberg, A. Lannuzel, O. Laprevote, A. Laurens, and R. Hocquemiller. Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe. Mov Disord, 20(12):1629-33, 2005. Note: Comparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tUnited Statesofficial journal of the Movement Disorder Society. [WWW] Keyword(s): Annona/*chemistry/toxicity, Chromatography, High Pressure Liquid/methods, Fatty Alcohols/*adverse effects/*analysis/chemistry, Guadeloupe/epidemiology, Humans, Lactones/*adverse effects/*analysis/chemistry, Molecular Weight, Parkinsonian Disorders/*etiology, Plant Extracts/adverse effects/analysis/chemistry, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods.



13. G. U. Hoglinger, A. Lannuzel, M. E. Khondiker, P. P. Michel, C. Duyckaerts, J. Feger, P. Champy, A. Prigent, F. Medja, A. Lombes, W. H. Oertel, M. Ruberg, and E. C. Hirsch. The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy. J Neurochem, 95(4):930-9, 2005. Note: Comparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tEngland. [WWW] Keyword(s): Amyloid beta-Protein/metabolism, Analysis of Variance, Animals, Antineoplastic Combined Chemotherapy Protocols/metabolism, Behavior, Animal, Body Weight/drug effects, Caspase 3, Caspases/metabolism, Cell Death/drug effects, Cerebral Cortex/*drug effects/pathology/physiopathology, Cytarabine/metabolism, Diagnostic Imaging/methods, Dopamine and cAMP-Regulated Phosphoprotein 32/metabolism, Doxorubicin/metabolism, Dystonia/etiology/physiopathology, Electron Transport Complex III/metabolism, Enzyme Activation/drug effects, Glial Fibrillary Acidic Protein/metabolism, Immunohistochemistry/methods, Locomotion/drug effects, Male, Microscopy, Electron, Transmission/methods, Mitochondria/drug effects/ultrastructure, Neurons/drug effects/physiology, Phosphopyruvate Hydratase/metabolism, Phosphorylation, Posture, Psychomotor Performance/drug effects, Rats, Rats, Inbred Lew, Rotenone/*adverse effects, Tauopathies/*chemically induced/pathology/physiopathology, Thiazoles/diagnostic use, Time Factors, Tyrosine/analogs & derivatives/metabolism, Tyrosine 3-Monooxygenase/metabolism, Ubiquitin/metabolism, Uncoupling Agents/*adverse effects, alpha-Synuclein/metabolism, tau Proteins/metabolism.



14. G. U. Hoglinger, P. P. Michel, P. Champy, J. Feger, E. C. Hirsch, M. Ruberg, and A. Lannuzel. Experimental evidence for a toxic etiology of tropical parkinsonism. Mov Disord, 20(1):118-9, 2005. Note: CommentComparative StudyLetterUnited Statesofficial journal of the Movement Disorder Society. [WWW] Keyword(s): Adenosine Triphosphate/metabolism, Alkaloids/toxicity, Animals, Annonaceae/chemistry/*toxicity, Brain/cytology/drug effects, Cells, Cultured, Fatty Alcohols/toxicity, Humans, Lactones/toxicity, Mitochondrial Diseases/complications/etiology, Neurons/drug effects, Pacific Islands, Parkinsonian Disorders/*etiology, Rats.



15. P. Champy, G. U. Hoglinger, J. Feger, C. Gleye, R. Hocquemiller, A. Laurens, V. Guerineau, O. Laprevote, F. Medja, A. Lombes, P. P. Michel, A. Lannuzel, E. C. Hirsch, and M. Ruberg. Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe. J Neurochem, 88(1):63-9, 2004. Note: Journal ArticleResearch Support, Non-U.S. Gov'tEngland. [WWW] Keyword(s): Adenosine Triphosphate/metabolism, Animals, Behavior, Animal/drug effects, Cell Count, Corpus Striatum/*drug effects/metabolism/pathology, Electron Transport Complex I/*antagonists & inhibitors, Furans/administration & dosage/*toxicity, Gliosis/chemically induced/pathology, Guadeloupe, Infusions, Intravenous, Lactones/administration & dosage/*toxicity, Male, Mitochondria/enzymology, Neurodegenerative Diseases/*chemically induced/enzymology/pathology, Neurons/drug effects/pathology, Parkinsonian Disorders/etiology, Plant Extracts/administration & dosage/*toxicity, Rats, Rats, Inbred Lew, Substantia Nigra/*drug effects/metabolism/pathology.



16. G. U. Hoglinger, P. Rizk, M. P. Muriel, C. Duyckaerts, W. H. Oertel, I. Caille, and E. C. Hirsch. Dopamine depletion impairs precursor cell proliferation in Parkinson disease. Nat Neurosci, 7(7):726-35, 2004. Note: Comparative StudyJournal ArticleResearch Support, U.S. Gov't, P.H.S.United States. [WWW] Keyword(s): Aged, Analysis of Variance, Animals, Antiparkinson Agents/therapeutic use, Bromodeoxyuridine/metabolism, Case-Control Studies, Cell Count/methods, Cell Death/physiology, Cell Division/drug effects, Cells, Cultured, Dopamine/*deficiency/physiology, Dopamine Antagonists/pharmacology, Dopamine Plasma Membrane Transport Proteins, Drug Interactions, Ependyma/ultrastructure, Female, Glial Fibrillary Acidic Protein/metabolism, Glycoproteins/metabolism, Humans, Immunohistochemistry/methods, In Situ Nick-End Labeling/methods, Indoles/therapeutic use, Intermediate Filament Proteins/metabolism, Levodopa/therapeutic use, Male, Membrane Glycoproteins/metabolism, Membrane Transport Proteins/metabolism, Mice, Mice, Inbred C57BL, Microscopy, Confocal/methods, Microscopy, Immunoelectron/methods, Microspheres, Middle Aged, Nerve Tissue Proteins/metabolism, Neural Cell Adhesion Molecule L1/metabolism, Neurons/metabolism/*pathology/ultrastructure, Olfactory Bulb/cytology/metabolism, Oxidopamine/toxicity, Parkinson Disease/drug therapy/*metabolism/*pathology, Parkinsonian Disorders/metabolism/pathology, Postmortem Changes, Rats, Rats, Sprague-Dawley, Receptor, Epidermal Growth Factor.



17. G. U. Hoglinger, G. Carrard, P. P. Michel, F. Medja, A. Lombes, M. Ruberg, B. Friguet, and E. C. Hirsch. Dysfunction of mitochondrial complex I and the proteasome: interactions between two biochemical deficits in a cellular model of Parkinson's disease. J Neurochem, 86(5):1297-307, 2003. Note: Journal ArticleResearch Support, Non-U.S. Gov'tEngland. [WWW] Keyword(s): 1-Methyl-4-phenylpyridinium/toxicity, Adenosine Triphosphate/metabolism, Animals, Cell Death, Cells, Cultured, Cysteine Endopeptidases/*metabolism, Dose-Response Relationship, Drug, Electron Transport Complex I, Enzyme Inhibitors/toxicity, Mesencephalon/cytology/embryology, Multienzyme Complexes/antagonists & inhibitors/*metabolism, NADH, NADPH Oxidoreductases/antagonists & inhibitors/*metabolism, Neurons/drug effects/*metabolism/pathology, Neurotoxins/toxicity, Oxidation-Reduction/drug effects, Parkinsonian Disorders/*metabolism/pathology, Proteasome Endopeptidase Complex, Rats, Rats, Wistar, Reactive Oxygen Species/metabolism, Rotenone/toxicity, Uncoupling Agents/toxicity.



18. G. U. Hoglinger, J. Feger, A. Prigent, P. P. Michel, K. Parain, P. Champy, M. Ruberg, W. H. Oertel, and E. C. Hirsch. Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats. J Neurochem, 84(3):491-502, 2003. Note: Journal ArticleResearch Support, Non-U.S. Gov'tEngland. [WWW] Keyword(s): Animals, Behavior, Animal/drug effects, Cell Count, Choline O-Acetyltransferase/biosynthesis, Chronic Disease, Corpus Striatum/drug effects/pathology, Disease Models, Animal, Dopamine and cAMP-Regulated Phosphoprotein 32, Drug Administration Schedule, Electron Transport Complex I, Enzyme Inhibitors/administration & dosage/*toxicity, Inclusion Bodies/pathology, Infusions, Intravenous, Locus Coeruleus/drug effects/pathology, Male, Mesencephalon/drug effects/pathology, Motor Activity/drug effects, Movement Disorders/complications/etiology/*pathology, NADH, NADPH Oxidoreductases/*antagonists & inhibitors, *Nerve Tissue Proteins, Neurodegenerative Diseases/chemically induced/complications/*pathology, Neuroglia/pathology, Neurons/drug effects/metabolism/pathology, Pesticides/toxicity, Phosphoproteins/biosynthesis, Rats, Rats, Inbred Lew, Rotenone/administration & dosage/*toxicity, Serotonin/biosynthesis, Substantia Nigra/drug effects/pathology, Time, Tyrosine 3-Monooxygenase/biosynthesis.



19. A. Lannuzel, P. P. Michel, G. U. Hoglinger, P. Champy, A. Jousset, F. Medja, A. Lombes, F. Darios, C. Gleye, A. Laurens, R. Hocquemiller, E. C. Hirsch, and M. Ruberg. The mitochondrial complex I inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism. Neuroscience, 121(2):287-96, 2003. Note: Comparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tUnited States. [WWW] Keyword(s): 1-Methyl-4-phenylpyridinium/toxicity, Acetylcysteine/pharmacology, Adenosine Triphosphate/analysis, Animals, Antioxidants/pharmacology, Benzodiazepines/pharmacology, Cell Survival, Cells, Cultured, Chromans/pharmacology, Deoxyglucose/metabolism, Dizocilpine Maleate/pharmacology, Dopamine/*metabolism, Dose-Response Relationship, Drug, Drug Interactions, Embryo, Energy Metabolism/*drug effects/physiology, Excitatory Amino Acid Antagonists, Female, Furans/chemistry/*toxicity, Glucose/pharmacology, Herbicides/toxicity, Hexoses/pharmacology, Insecticides/toxicity, Intracellular Space/metabolism, Lactones/chemistry/*toxicity, Male, Mannose/pharmacology, Mesencephalon/cytology/*drug effects/physiology, Microtubule-Associated Proteins/metabolism, Mitochondria/*drug effects, Neurons/*drug effects/physiology, Neurotoxins/chemistry/*toxicity, Plant Extracts/chemistry/toxicity, Pregnancy, Rats, Rats, Wistar, Reactive Oxygen Species, Rotenone/toxicity, Tritium/metabolism, Tyrosine 3-Monooxygenase/metabolism.

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