1. S. Guerreiro, A. Ponceau, D. Toulorge, E. Martin, D. Alvarez-Fischer, E. C. Hirsch, and P. P. Michel. Protection of Midbrain Dopaminergic Neurons by the End-Product of Purine Metabolism Uric Acid: Potentiation by Low-Level Depolarization. J Neurochem, 109(4):1118-1128, 2009. Note: Journal article. [WWW]



2. D. Alvarez-Fischer, S. Guerreiro, S. Hunot, F. Saurini, M. Marien, P. Sokoloff, E. C. Hirsch, A. Hartmann, and P. P. Michel. Modelling Parkinson-like neurodegeneration via osmotic minipump delivery of MPTP and probenecid. J Neurochem, 107(3):701-11, 2008. Note: Journal ArticleResearch Support, Non-U.S. Gov'tEngland. [WWW] Keyword(s): 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine/*administration & dosage, Adjuvants, Pharmaceutic/administration & dosage, Animals, Brain/drug effects/pathology, Chromatography, High Pressure Liquid, *Disease Models, Animal, Dopamine/analysis/metabolism, Immunohistochemistry, *Infusion Pumps, Male, Mice, Mice, Inbred C57BL, Nerve Degeneration/chemically induced, Neurotoxins/*administration & dosage, Parkinsonian Disorders/*chemically induced, Probenecid/*administration & dosage.



3. S. Guerreiro, D. Toulorge, E. Hirsch, M. Marien, P. Sokoloff, and P. P. Michel. Paraxanthine, the Primary Metabolite of Caffeine, Provides Protection against Dopaminergic Cell Death via Stimulation of Ryanodine Receptor Channels. Mol Pharmacol, 74(4):980-9, 2008. Note: Journal ArticleUnited States. [WWW]



4. A. Lannuzel, M. Ruberg, and P. P. Michel. Atypical parkinsonism in the Caribbean island of Guadeloupe: etiological role of the mitochondrial complex I inhibitor annonacin. Mov Disord, 23(15):2122-8, 2008. Note: Journal ArticleResearch Support, Non-U.S. Gov'tReviewUnited Statesofficial journal of the Movement Disorder Society. [WWW] Keyword(s): Animals, Electron Transport Complex I/*antagonists & inhibitors, Furans/*administration & dosage, Guadeloupe/epidemiology, Humans, Lactones/*administration & dosage, Mitochondria/*drug effects/metabolism, Parkinsonian Disorders/epidemiology/*etiology/*pathology.



5. C. Salum, R. Raisman-Vozari, P. P. Michel, M. Z. Gomes, M. Mitkovski, J. E. Ferrario, L. Ginestet, and E. A. Del Bel. Modulation of dopamine uptake by nitric oxide in cultured mesencephalic neurons. Brain Res, 1198:27-33, 2008. Note: Journal ArticleNetherlands. [WWW]



6. C. Depboylu, A. Matusch, F. Tribl, M. Zoriy, P. P. Michel, P. Riederer, M. Gerlach, S. Becker, W. H. Oertel, and G. U. Hoglinger. Glia protects neurons against extracellular human neuromelanin. Neurodegener Dis, 4(2-3):218-26, 2007. Note: Journal ArticleResearch Support, Non-U.S. Gov'tSwitzerland. [WWW]



7. M. Escobar-Khondiker, M. Hollerhage, M. P. Muriel, P. Champy, A. Bach, C. Depienne, G. Respondek, E. S. Yamada, A. Lannuzel, T. Yagi, E. C. Hirsch, W. H. Oertel, R. Jacob, P. P. Michel, M. Ruberg, and G. U. Hoglinger. Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons. J Neurosci, 27(29):7827-37, 2007. Note: Dk053244/dk/niddkNs048441/ns/nindsJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tUnited Statesthe official journal of the Society for Neuroscience. [WWW] Keyword(s): Adenosine Triphosphate/metabolism, Animals, Brain/cytology, Cell Death/drug effects, Cell Survival/drug effects, Cells, Cultured, Dose-Response Relationship, Drug, Embryo, Enzyme Inhibitors/*pharmacology, Female, Furans/*pharmacology, Lactones/*pharmacology, Microscopy, Immunoelectron/methods, Microtubule-Associated Proteins/metabolism, Neurons/*drug effects/metabolism/ultrastructure, Paclitaxel/pharmacology, Pregnancy, Rats, Rats, Wistar, Reactive Oxygen Species/metabolism, Tubulin Modulators/pharmacology, tau Proteins/*metabolism.



8. G. U. Hoglinger, J. J. Breunig, C. Depboylu, C. Rouaux, P. P. Michel, D. Alvarez-Fischer, A. L. Boutillier, J. Degregori, W. H. Oertel, P. Rakic, E. C. Hirsch, and S. Hunot. The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease. Proc Natl Acad Sci U S A, 104(9):3585-90, 2007. Note: R24 mh 68855/mh/nimhComparative StudyJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tUnited States. [WWW] Keyword(s): 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine/pharmacology, 1-Methyl-4-phenylpyridinium/pharmacology, Analysis of Variance, Animals, Apoptosis/*physiology, Chromatography, High Pressure Liquid, E2F1 Transcription Factor/genetics/*metabolism, Gene Expression Regulation/drug effects, Humans, Immunohistochemistry, In Situ Hybridization, Interneurons/drug effects/*metabolism, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Oligonucleotides, Antisense/genetics, Parkinson Disease/*physiopathology, Signal Transduction/drug effects, Substantia Nigra/*metabolism.



9. P. P. Michel, D. Alvarez-Fischer, S. Guerreiro, A. Hild, A. Hartmann, and E. C. Hirsch. Role of activity-dependent mechanisms in the control of dopaminergic neuron survival. J Neurochem, 101(2):289-97, 2007. Note: Journal ArticleResearch Support, Non-U.S. Gov'tReviewEngland. [WWW] Keyword(s): Action Potentials/*physiology, Animals, Cell Survival/physiology, Dopamine/*metabolism, Humans, Ion Channels/*metabolism, Na(+)-K(+)-Exchanging ATPase/metabolism, Neurons/*metabolism, Parkinson Disease/metabolism/physiopathology, Receptors, Neurotransmitter/metabolism, Substantia Nigra/*metabolism.



10. A. Lannuzel, G. U. Hoglinger, P. Champy, P. P. Michel, E. C. Hirsch, and M. Ruberg. Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae?. J Neural Transm Suppl, (70):153-7, 2006. Note: Journal ArticleAustria. [WWW] Keyword(s): Adenosine Triphosphate/metabolism, Alkaloids/isolation & purification/toxicity, Animals, Annonaceae/*adverse effects, Cells, Cultured, Fruit, Furans/isolation & purification/toxicity, Lactones/isolation & purification/toxicity, Male, Medicine, Herbal, Mesencephalon/cytology, Neostriatum/pathology, Nerve Degeneration/chemically induced/pathology, Parkinson Disease, Secondary/*chemically induced/epidemiology, Plant Extracts/adverse effects, Plant Leaves/chemistry, Rats, Rats, Inbred Lew, Substantia Nigra/pathology, West Indies/epidemiology.



11. P. P. Michel, M. Ruberg, and E. Hirsch. Dopaminergic neurons reduced to silence by oxidative stress: an early step in the death cascade in Parkinson's disease?. Sci STKE, 2006(332):pe19, 2006. Note: Journal ArticleUnited Statessignal transduction knowledge environment. [WWW] Keyword(s): Animals, Cell Death, Dopamine/metabolism, Mice, Mitochondria/metabolism, Neurons/*metabolism/pathology/physiology, *Oxidative Stress, Parkinson Disease/*metabolism/pathology/physiopathology, Signal Transduction.



12. S. Traver, M. Marien, E. Martin, E. C. Hirsch, and P. P. Michel. The phenotypic differentiation of locus ceruleus noradrenergic neurons mediated by brain-derived neurotrophic factor is enhanced by corticotropin releasing factor through the activation of a cAMP-dependent signaling pathway. Mol Pharmacol, 70(1):30-40, 2006. Note: Journal ArticleResearch Support, Non-U.S. Gov'tUnited States. [WWW] Keyword(s): Animals, Blotting, Western, Brain-Derived Neurotrophic Factor/*pharmacology, Cell Differentiation/*drug effects, Cells, Cultured, Corticotropin-Releasing Hormone/*pharmacology, Cyclic AMP/*metabolism, Dose-Response Relationship, Drug, Drug Synergism, Enzyme Activation/drug effects, Gene Expression/drug effects, Locus Coeruleus/cytology/drug effects/metabolism, Mitogen-Activated Protein Kinase 1/metabolism, Mitogen-Activated Protein Kinase 3/metabolism, Neurons/cytology/*drug effects/metabolism, Norepinephrine/metabolism, Norepinephrine Plasma Membrane Transport Proteins/genetics/metabolism, Rats, Rats, Wistar, Receptor, trkB/genetics/metabolism, Receptors, Corticotropin-Releasing Hormone/genetics/metabolism, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction/*drug effects, Tyrosine 3-Monooxygenase/genetics/metabolism.



13. C. Henze, A. Hartmann, T. Lescot, E. C. Hirsch, and P. P. Michel. Proliferation of microglial cells induced by 1-methyl-4-phenylpyridinium in mesencephalic cultures results from an astrocyte-dependent mechanism: role of granulocyte macrophage colony-stimulating factor. J Neurochem, 95(4):1069-77, 2005. Note: Comparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tEngland. [WWW] Keyword(s): 1-Methyl-4-phenylpyridinium/*toxicity, Animals, Antigens, CD11c/metabolism, Astrocytes/*physiology, Cell Count/methods, Cell Proliferation/*drug effects, Cells, Cultured, Dose-Response Relationship, Drug, Drug Interactions, Embryo, Granulocyte-Macrophage Colony-Stimulating Factor/*pharmacology, Immunohistochemistry/methods, Mesencephalon/*cytology, Microglia/*drug effects/metabolism, Microtubule-Associated Proteins/metabolism, Rats, Tyrosine 3-Monooxygenase/metabolism.



14. C. Henze, T. Lescot, S. Traver, B. Salthun-Lassalle, E. C. Hirsch, P. P. Michel, and A. Hartmann. Granulocyte colony-stimulating factor is not protective against selective dopaminergic cell death in vitro. Neurosci Lett, 383(1-2):44-8, 2005. Note: Comparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tIreland. [WWW] Keyword(s): 1-Methyl-4-phenylpyridinium/toxicity, Analysis of Variance, Animals, Antigens, CD11b/metabolism, Cell Count/methods, Cell Death/*drug effects, Cell Proliferation/drug effects, Cells, Cultured, Cytarabine/toxicity, Dopamine/*metabolism, Dose-Response Relationship, Drug, Drug Interactions, Embryo, Glial Fibrillary Acidic Protein/metabolism, Granulocyte Colony-Stimulating Factor/*pharmacology, Herbicides/toxicity, Immunohistochemistry/methods, Microglia/drug effects/metabolism, Microtubule-Associated Proteins/metabolism, Neurons/cytology/*drug effects/metabolism, Rats, Thymidine/pharmacokinetics, Tritium/pharmacokinetics, Tyrosine 3-Monooxygenase/metabolism, Vimentin/metabolism.



15. G. U. Hoglinger, A. Lannuzel, M. E. Khondiker, P. P. Michel, C. Duyckaerts, J. Feger, P. Champy, A. Prigent, F. Medja, A. Lombes, W. H. Oertel, M. Ruberg, and E. C. Hirsch. The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy. J Neurochem, 95(4):930-9, 2005. Note: Comparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tEngland. [WWW] Keyword(s): Amyloid beta-Protein/metabolism, Analysis of Variance, Animals, Antineoplastic Combined Chemotherapy Protocols/metabolism, Behavior, Animal, Body Weight/drug effects, Caspase 3, Caspases/metabolism, Cell Death/drug effects, Cerebral Cortex/*drug effects/pathology/physiopathology, Cytarabine/metabolism, Diagnostic Imaging/methods, Dopamine and cAMP-Regulated Phosphoprotein 32/metabolism, Doxorubicin/metabolism, Dystonia/etiology/physiopathology, Electron Transport Complex III/metabolism, Enzyme Activation/drug effects, Glial Fibrillary Acidic Protein/metabolism, Immunohistochemistry/methods, Locomotion/drug effects, Male, Microscopy, Electron, Transmission/methods, Mitochondria/drug effects/ultrastructure, Neurons/drug effects/physiology, Phosphopyruvate Hydratase/metabolism, Phosphorylation, Posture, Psychomotor Performance/drug effects, Rats, Rats, Inbred Lew, Rotenone/*adverse effects, Tauopathies/*chemically induced/pathology/physiopathology, Thiazoles/diagnostic use, Time Factors, Tyrosine/analogs & derivatives/metabolism, Tyrosine 3-Monooxygenase/metabolism, Ubiquitin/metabolism, Uncoupling Agents/*adverse effects, alpha-Synuclein/metabolism, tau Proteins/metabolism.



16. G. U. Hoglinger, P. P. Michel, P. Champy, J. Feger, E. C. Hirsch, M. Ruberg, and A. Lannuzel. Experimental evidence for a toxic etiology of tropical parkinsonism. Mov Disord, 20(1):118-9, 2005. Note: CommentComparative StudyLetterUnited Statesofficial journal of the Movement Disorder Society. [WWW] Keyword(s): Adenosine Triphosphate/metabolism, Alkaloids/toxicity, Animals, Annonaceae/chemistry/*toxicity, Brain/cytology/drug effects, Cells, Cultured, Fatty Alcohols/toxicity, Humans, Lactones/toxicity, Mitochondrial Diseases/complications/etiology, Neurons/drug effects, Pacific Islands, Parkinsonian Disorders/*etiology, Rats.



17. B. Salthun-Lassalle, S. Traver, E. C. Hirsch, and P. P. Michel. Substance P, neurokinins A and B, and synthetic tachykinin peptides protect mesencephalic dopaminergic neurons in culture via an activity-dependent mechanism. Mol Pharmacol, 68(5):1214-24, 2005. Note: Journal ArticleResearch Support, Non-U.S. Gov'tUnited States. [WWW] Keyword(s): Animals, Calcium Channels, N-Type/physiology, Cell Count, Cell Survival/drug effects, Dopamine/*physiology, Ion Channel Gating, Mesencephalon/cytology/*drug effects, Neurokinin A/*pharmacology, Neurokinin B/*pharmacology, Neurons/cytology/*drug effects/metabolism, Neuroprotective Agents/*pharmacology, Rats, Rats, Wistar, Receptors, Neurokinin-1/physiology, Receptors, Neurokinin-3/physiology, Sodium Channels/physiology, Substance P/*pharmacology, Tetrodotoxin/pharmacology.



18. S. Traver, B. Salthun-Lassalle, M. Marien, E. C. Hirsch, F. Colpaert, and P. P. Michel. The neurotransmitter noradrenaline rescues septal cholinergic neurons in culture from degeneration caused by low-level oxidative stress. Mol Pharmacol, 67(6):1882-91, 2005. Note: Comparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tUnited States. [WWW] Keyword(s): Animals, Cells, Cultured, Choline O-Acetyltransferase/antagonists & inhibitors/metabolism, Cholinergic Fibers/*drug effects/metabolism, Dose-Response Relationship, Drug, Nerve Degeneration/metabolism/pathology/*prevention & control, Neurons/cytology/drug effects/metabolism, Neuroprotective Agents/pharmacology/therapeutic use, Norepinephrine/*pharmacology/therapeutic use, Oxidative Stress/*drug effects/physiology, Rats, Rats, Wistar, Septum of Brain/cytology/*drug effects/metabolism.



19. P. Champy, G. U. Hoglinger, J. Feger, C. Gleye, R. Hocquemiller, A. Laurens, V. Guerineau, O. Laprevote, F. Medja, A. Lombes, P. P. Michel, A. Lannuzel, E. C. Hirsch, and M. Ruberg. Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe. J Neurochem, 88(1):63-9, 2004. Note: Journal ArticleResearch Support, Non-U.S. Gov'tEngland. [WWW] Keyword(s): Adenosine Triphosphate/metabolism, Animals, Behavior, Animal/drug effects, Cell Count, Corpus Striatum/*drug effects/metabolism/pathology, Electron Transport Complex I/*antagonists & inhibitors, Furans/administration & dosage/*toxicity, Gliosis/chemically induced/pathology, Guadeloupe, Infusions, Intravenous, Lactones/administration & dosage/*toxicity, Male, Mitochondria/enzymology, Neurodegenerative Diseases/*chemically induced/enzymology/pathology, Neurons/drug effects/pathology, Parkinsonian Disorders/etiology, Plant Extracts/administration & dosage/*toxicity, Rats, Rats, Inbred Lew, Substantia Nigra/*drug effects/metabolism/pathology.



20. B. Salthun-Lassalle, E. C. Hirsch, J. Wolfart, M. Ruberg, and P. P. Michel. Rescue of mesencephalic dopaminergic neurons in culture by low-level stimulation of voltage-gated sodium channels. J Neurosci, 24(26):5922-30, 2004. Note: Journal ArticleResearch Support, Non-U.S. Gov'tUnited Statesthe official journal of the Society for Neuroscience. [WWW] Keyword(s): Animals, Apamin/pharmacology, Apoptosis/drug effects, Aspirin/pharmacology, Biological Transport, Active/drug effects, Calcium Channel Agonists/pharmacology, Calcium Channel Blockers/pharmacology, Calcium Channels, T-Type/drug effects, Cells, Cultured/cytology/drug effects/metabolism, Dopamine/*metabolism, Glial Cell Line-Derived Neurotrophic Factor, Ion Channel Gating, Ion Transport/drug effects, Mesencephalon/*cytology, Na(+)-K(+)-Exchanging ATPase/antagonists & inhibitors/physiology, Nerve Growth Factors/pharmacology, Nerve Tissue Proteins/*drug effects/physiology, Neurons/cytology/*drug effects/metabolism, Neuroprotective Agents/*pharmacology, Nifedipine/pharmacology, Ouabain/pharmacology, Potassium Channel Blockers/pharmacology, Potassium Channels, Calcium-Activated/antagonists & inhibitors, Rats, Rats, Wistar, Scorpion Venoms/pharmacology, Serotonin/metabolism, Sodium/pharmacology/*physiology, Sodium Channel Blockers/*pharmacology, Sodium Channels/*drug effects/physiology, Tetrodotoxin/pharmacology, Veratridine/*pharmacology, gamma-Aminobutyric Acid/metabolism.



21. F. Darios, N. Lambeng, J. D. Troadec, P. P. Michel, and M. Ruberg. Ceramide increases mitochondrial free calcium levels via caspase 8 and Bid: role in initiation of cell death. J Neurochem, 84(4):643-54, 2003. Note: Journal ArticleResearch Support, Non-U.S. Gov'tEngland. [WWW] Keyword(s): Animals, Apoptosis/drug effects/physiology, BH3 Interacting Domain Death Agonist Protein, Calcium/*metabolism, Carrier Proteins/*metabolism, Caspase 8, Caspase 9, Caspases/*metabolism, Cell Differentiation/drug effects, Ceramides/*pharmacology, Cytochrome c Group/metabolism, Endoplasmic Reticulum/metabolism, Mitochondria/drug effects/*metabolism, Nerve Growth Factor/pharmacology, Neurons/drug effects/metabolism, PC12 Cells, Rats, Reactive Oxygen Species/metabolism, Sphingosine/*analogs & derivatives/pharmacology.



22. A. Douhou, T. Debeir, P. P. Michel, L. Stankovski, L. Oueghlani-Bouslama, C. Verney, and R. Raisman-Vozari. Differential activation of astrocytes and microglia during post-natal development of dopaminergic neuronal death in the weaver mouse. Brain Res Dev Brain Res, 145(1):9-17, 2003. Note: Comparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tNetherlands. [WWW] Keyword(s): Aging, Animals, Animals, Newborn, Astrocytes/*physiology, Cell Count, Cell Death/*physiology, Dopamine/*metabolism, Glial Fibrillary Acidic Protein/metabolism, Homozygote, Immunohistochemistry, Macrophage-1 Antigen/metabolism, Mesencephalon/anatomy & histology/growth & development/metabolism, Mice, Mice, Neurologic Mutants, Microglia/*physiology, Neurons/*physiology, Tyrosine 3-Monooxygenase/metabolism.



23. E. C. Hirsch, T. Breidert, E. Rousselet, S. Hunot, A. Hartmann, and P. P. Michel. The role of glial reaction and inflammation in Parkinson's disease. Ann N Y Acad Sci, 991:214-28, 2003. Note: Journal ArticleReviewUnited States. [WWW] Keyword(s): Animals, Anti-Inflammatory Agents/therapeutic use, Cytokines/metabolism, Dopamine/metabolism, Humans, Inflammation/etiology, Nerve Degeneration/physiopathology, *Neuroglia, Neurons/metabolism, Parkinson Disease/metabolism/pathology/*physiopathology.



24. G. U. Hoglinger, G. Carrard, P. P. Michel, F. Medja, A. Lombes, M. Ruberg, B. Friguet, and E. C. Hirsch. Dysfunction of mitochondrial complex I and the proteasome: interactions between two biochemical deficits in a cellular model of Parkinson's disease. J Neurochem, 86(5):1297-307, 2003. Note: Journal ArticleResearch Support, Non-U.S. Gov'tEngland. [WWW] Keyword(s): 1-Methyl-4-phenylpyridinium/toxicity, Adenosine Triphosphate/metabolism, Animals, Cell Death, Cells, Cultured, Cysteine Endopeptidases/*metabolism, Dose-Response Relationship, Drug, Electron Transport Complex I, Enzyme Inhibitors/toxicity, Mesencephalon/cytology/embryology, Multienzyme Complexes/antagonists & inhibitors/*metabolism, NADH, NADPH Oxidoreductases/antagonists & inhibitors/*metabolism, Neurons/drug effects/*metabolism/pathology, Neurotoxins/toxicity, Oxidation-Reduction/drug effects, Parkinsonian Disorders/*metabolism/pathology, Proteasome Endopeptidase Complex, Rats, Rats, Wistar, Reactive Oxygen Species/metabolism, Rotenone/toxicity, Uncoupling Agents/toxicity.



25. G. U. Hoglinger, J. Feger, A. Prigent, P. P. Michel, K. Parain, P. Champy, M. Ruberg, W. H. Oertel, and E. C. Hirsch. Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats. J Neurochem, 84(3):491-502, 2003. Note: Journal ArticleResearch Support, Non-U.S. Gov'tEngland. [WWW] Keyword(s): Animals, Behavior, Animal/drug effects, Cell Count, Choline O-Acetyltransferase/biosynthesis, Chronic Disease, Corpus Striatum/drug effects/pathology, Disease Models, Animal, Dopamine and cAMP-Regulated Phosphoprotein 32, Drug Administration Schedule, Electron Transport Complex I, Enzyme Inhibitors/administration & dosage/*toxicity, Inclusion Bodies/pathology, Infusions, Intravenous, Locus Coeruleus/drug effects/pathology, Male, Mesencephalon/drug effects/pathology, Motor Activity/drug effects, Movement Disorders/complications/etiology/*pathology, NADH, NADPH Oxidoreductases/*antagonists & inhibitors, *Nerve Tissue Proteins, Neurodegenerative Diseases/chemically induced/complications/*pathology, Neuroglia/pathology, Neurons/drug effects/metabolism/pathology, Pesticides/toxicity, Phosphoproteins/biosynthesis, Rats, Rats, Inbred Lew, Rotenone/administration & dosage/*toxicity, Serotonin/biosynthesis, Substantia Nigra/drug effects/pathology, Time, Tyrosine 3-Monooxygenase/biosynthesis.



26. A. Lannuzel, P. P. Michel, G. U. Hoglinger, P. Champy, A. Jousset, F. Medja, A. Lombes, F. Darios, C. Gleye, A. Laurens, R. Hocquemiller, E. C. Hirsch, and M. Ruberg. The mitochondrial complex I inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism. Neuroscience, 121(2):287-96, 2003. Note: Comparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tUnited States. [WWW] Keyword(s): 1-Methyl-4-phenylpyridinium/toxicity, Acetylcysteine/pharmacology, Adenosine Triphosphate/analysis, Animals, Antioxidants/pharmacology, Benzodiazepines/pharmacology, Cell Survival, Cells, Cultured, Chromans/pharmacology, Deoxyglucose/metabolism, Dizocilpine Maleate/pharmacology, Dopamine/*metabolism, Dose-Response Relationship, Drug, Drug Interactions, Embryo, Energy Metabolism/*drug effects/physiology, Excitatory Amino Acid Antagonists, Female, Furans/chemistry/*toxicity, Glucose/pharmacology, Herbicides/toxicity, Hexoses/pharmacology, Insecticides/toxicity, Intracellular Space/metabolism, Lactones/chemistry/*toxicity, Male, Mannose/pharmacology, Mesencephalon/cytology/*drug effects/physiology, Microtubule-Associated Proteins/metabolism, Mitochondria/*drug effects, Neurons/*drug effects/physiology, Neurotoxins/chemistry/*toxicity, Plant Extracts/chemistry/toxicity, Pregnancy, Rats, Rats, Wistar, Reactive Oxygen Species, Rotenone/toxicity, Tritium/metabolism, Tyrosine 3-Monooxygenase/metabolism.



27. S. Mourlevat, J. D. Troadec, M. Ruberg, and P. P. Michel. Prevention of dopaminergic neuronal death by cyclic AMP in mixed neuronal/glial mesencephalic cultures requires the repression of presumptive astrocytes. Mol Pharmacol, 64(3):578-86, 2003. Note: Journal ArticleResearch Support, Non-U.S. Gov'tUnited States. [WWW] Keyword(s): Animals, Astrocytes/*drug effects/physiology, Cell Death/drug effects/physiology, Coculture Techniques, Cyclic AMP/*pharmacology, Dopamine/*physiology, Female, Mesencephalon/cytology/*drug effects/physiology, Neuroglia/drug effects/physiology, Neurons/*drug effects/physiology, Rats, Rats, Wistar.

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